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Refine Technology

Refine Technology

The ATF™ System from Refine Technology is changing the way cell culture is performed. The patented system uses alternating tangential flow filtration to increase cell density, expression and provides 0.2 micron filtered supernatant ready for downstream process steps. The ATF system is now widely in use for both research & GMP applications.

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Refine Technology

The ATF™ System : Redefining Cell Culture

Increase Expression : >1 gm/liter/day

The ATF System from Refine Technology will change how you think about cell culture. The system uses alternating tangential flow filtration to grow cells up to extremely high densities. The natural and gentle reciprocating nature of the device provides 0.2um filtered supernatent ready for downstream process applications. Some of the features and benefits end-users experience when implementing the ATF are outlined are listed below:

  • High Cell Density : 150 million/ml attained.
  • Multiple Modes : Works well in perfusion, fed-batch or hybrid processes .
  • Multiple Cell Lines : Use it with mammalian, microbial and insect cell lines.
  • Versitile : Special cartridges for micro-carriers
  • Linearly Scaleable : Easy tech transfer from research to production
  • Accepted : In-use at biopharm companies worldwide.

Literature Link


The Factory of the Future
The Factory of the Future
Introducing new technologies and methodologies into process development and manufacturing facilities should lead to improvements and efficiency gains in those facilities.
Technical Background
Technical Background
The ATF™ System was originally designed for perfusion processes in mammalian cell culture. Learn about the history and advances of the ATF.
ATF System Applications
Applications
To maximize your results, understand how the ATF System operates in different applications.
Cell/Product Type
Cell/Product Type
Learn about the various types of cell lines used with the ATF System and review the benefit provided when processed using the technology.
Microcarriers, Adherent Cells
Microcarriers, Adherent Cells
Microcarrier processes are inherently more complex and more involved than concentrated fed-batch or fed-batch processes.
Unit Operations
Unit Operations
Learn how the ATF System can make existing unit operations, such as Fed-Batch, more productive & efficient.
Process Comparison
Process Comparison
Information to help with the many key decisions about how to proceed, including choosing a cell line, whether to outsource or keep in-house, and what type of bioprocess is most economic.